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Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity
Excessive accumulation of amyloid β-peptide (Aβ) plays an early and critical role in synapse and neuronal loss in Alzheimer's Disease (AD). Increased oxidative stress is one of the mechanisms whereby Aβ induces neuronal death. Given the lessened susceptibility to oxidative stress exhibited by m...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171879/ https://ncbi.nlm.nih.gov/pubmed/15837797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410041 |
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