Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity

Excessive accumulation of amyloid β-peptide (Aβ) plays an early and critical role in synapse and neuronal loss in Alzheimer's Disease (AD). Increased oxidative stress is one of the mechanisms whereby Aβ induces neuronal death. Given the lessened susceptibility to oxidative stress exhibited by m...

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Detalhes bibliográficos
Main Authors: Smith, Wanli W., Norton, Darrell D., Gorospe, Myriam, Jiang, Haibing, Nemoto, Shino, Holbrook, Nikki J., Finkel, Toren, Kusiak, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171879/
https://ncbi.nlm.nih.gov/pubmed/15837797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410041
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