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Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation during development and in pathological conditions. In this study, we demonstrate that VEGF bioavailability is regulated extracellularly by matrix metalloproteinases (MMPs) through intramolecular processing. Sp...

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Bibliografski detalji
Glavni autori: Lee, Sunyoung, Jilani, Shahla M., Nikolova, Ganka V., Carpizo, Darren, Iruela-Arispe, M. Luisa
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171712/
https://ncbi.nlm.nih.gov/pubmed/15911882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409115
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