Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

Growth of tumors and metastasis are processes known to require neovascularization. To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in the mamm...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rodríguez-Manzaneque, Juan Carlos, Lane, Timothy F., Ortega, María Asunción, Hynes, Richard O., Lawler, Jack, Iruela-Arispe, M. Luisa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606713/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171460498
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