Src-like adaptor protein down-regulates T cell receptor (TCR)–CD3 expression by targeting TCRζ for degradation

Src-like adaptor protein (SLAP) down-regulates expression of the T cell receptor (TCR)–CD3 complex during a specific stage of thymocyte development when the TCR repertoire is selected. Consequently, SLAP−/− thymocytes display alterations in thymocyte development. Here, we have studied the mechanism...

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Autores principales: Myers, Margaret D., Dragone, Leonard L., Weiss, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171412/
https://ncbi.nlm.nih.gov/pubmed/16027224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200501164
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