Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer

Lysosomal storage is the most common cause of neurodegenerative brain disease in preadulthood. However, the underlying cellular mechanisms that lead to neuronal dysfunction are unknown. Here, we report that loss of Drosophila benchwarmer (bnch), a predicted lysosomal sugar carrier, leads to carbohyd...

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Autori principali: Dermaut, Bart, Norga, Koenraad K., Kania, Artur, Verstreken, Patrik, Pan, Hongling, Zhou, Yi, Callaerts, Patrick, Bellen, Hugo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2005
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171373/
https://ncbi.nlm.nih.gov/pubmed/15998804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200412001
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