Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

Emery-Dreifuss muscular dystrophy can be caused by mutations in the nuclear envelope proteins lamin A/C and emerin. We recently demonstrated that A-type lamin-deficient cells have impaired nuclear mechanics and altered mechanotransduction, suggesting two potential disease mechanisms (Lammerding, J.,...

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Autores principales: Lammerding, Jan, Hsiao, Janet, Schulze, P. Christian, Kozlov, Serguei, Stewart, Colin L., Lee, Richard T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171355/
https://ncbi.nlm.nih.gov/pubmed/16115958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200502148
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