PTP-1B is an essential positive regulator of platelet integrin signaling

Outside-in integrin αIIbβ3 signaling is required for normal platelet thrombus formation and is triggered by c-Src activation through an unknown mechanism. In this study, we demonstrate an essential role for protein–tyrosine phosphatase (PTP)–1B in this process. In resting platelets, c-Src forms a co...

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Main Authors: Arias-Salgado, Elena Garcia, Haj, Fawaz, Dubois, Christophe, Moran, Barry, Kasirer-Friede, Ana, Furie, Barbara C., Furie, Bruce, Neel, Benjamin G., Shattil, Sanford J.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171339/
https://ncbi.nlm.nih.gov/pubmed/16115959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200503125
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