Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells

Upon cross-linking by antigen, the high affinity receptor for immunoglobulin E (IgE), FcɛRI, is phosphorylated by the Src family tyrosine kinase Lyn to initiate mast cell signaling, leading to degranulation. Using fluorescence correlation spectroscopy (FCS), we observe stimulation-dependent associat...

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Detalhes bibliográficos
Main Authors: Larson, Daniel R., Gosse, Julie A., Holowka, David A., Baird, Barbara A., Webb, Watt W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171255/
https://ncbi.nlm.nih.gov/pubmed/16275755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200503110
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