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A Na(v)1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Mutations in the TTX-sensitive voltage-gated sodium channel subtype Na(v)1.7 have been implicated in the painful inherited neuropathy, hereditary erythromelalgia. Hereditary erythromelalgia can be difficult to treat and, although sodium channels are targeted by local anaesthetics such as lidocaine (...

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Main Authors: Sheets, Patrick L, Jackson, James O, Waxman, Stephen G, Dib-Hajj, Sulayman D, Cummins, Theodore R
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170829/
https://ncbi.nlm.nih.gov/pubmed/17430993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.127027
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