Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K(+) channels

The G-protein gated inward rectifier K(+) channel (GIRK) is activated in vivo by the Gβγ subunits liberated upon G(i)-coupled receptor activation. We have recapitulated the acute desensitization of receptor-activated GIRK currents in heterologous systems and shown that it is a membrane-delimited pro...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chuang, Huai-hu, Yu, Mei, Jan, Yuh Nung, Jan, Lily Yeh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11727
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