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Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K(+) channels

The G-protein gated inward rectifier K(+) channel (GIRK) is activated in vivo by the Gβγ subunits liberated upon G(i)-coupled receptor activation. We have recapitulated the acute desensitization of receptor-activated GIRK currents in heterologous systems and shown that it is a membrane-delimited pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Chuang, Huai-hu, Yu, Mei, Jan, Yuh Nung, Jan, Lily Yeh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1998
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC21708/
https://ncbi.nlm.nih.gov/pubmed/9751733
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