Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients

BACKGROUND—More than 50% of patients with Parkinson's disease develop motor response fluctuations (the "wearing off" phenomenon) after more than five years of levodopa therapy. Inhibition of catechol-O-methyltransferase by tolcapone has been shown to increase levodopa bioavailability...

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Autores principales: Baas, H, Beiske, A, Ghika, J, Jackson, M, Oertel, W, Poewe, W, Ransmayr, G
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Group 1997
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169755/
https://ncbi.nlm.nih.gov/pubmed/9343116
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