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Transcription Factor Sp3 Knockout Mice Display Serious Cardiac Malformations
Mice lacking the zinc finger transcription factor specificity protein 3 (Sp3) die prenatally in the C57BL/6 background. To elucidate the cause of mortality we analyzed the potential role of Sp3 in embryonic heart development. Sp3 null hearts display defective looping at embryonic day 10.5 (E10.5), a...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2169408/ https://ncbi.nlm.nih.gov/pubmed/17923686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01350-07 |
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