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Phosphatidylinositol 3-Kinase Activation Is Required To Form the NKG2D Immunological Synapse

The receptor NKG2D allows natural killer (NK) cells to detect virally infected, stressed, and tumor cells. In human cells, NKG2D signaling is mediated through the associated DAP10 adapter. Here we show that engagement of NKG2D by itself is sufficient to stimulate the formation of the NK immunologica...

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Bibliografske podrobnosti
Main Authors: Giurisato, Emanuele, Cella, Marina, Takai, Toshiyuki, Kurosaki, Tomohiro, Feng, Yungfeng, Longmore, Gregory D., Colonna, Marco, Shaw, Andrey S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169389/
https://ncbi.nlm.nih.gov/pubmed/17923698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01477-07
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