Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates

Antagonist affinity measurements have traditionally been considered important in characterizing the cell-surface receptors present in a particular cell or tissue. A central assumption has been that antagonist affinity is constant for a given receptor–antagonist interaction, regardless of the agonist...

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Dettagli Bibliografici
Autori principali: Baker, Jillian G., Hill, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Published By Elsevier In Association With The International Union Of Pharmacology 2007
Soggetti:
Opinion

Special issue: Allosterism and Collateral Efficacy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169386/
https://ncbi.nlm.nih.gov/pubmed/17629959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2007.06.011
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