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Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates
Antagonist affinity measurements have traditionally been considered important in characterizing the cell-surface receptors present in a particular cell or tissue. A central assumption has been that antagonist affinity is constant for a given receptor–antagonist interaction, regardless of the agonist...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Published By Elsevier In Association With The International Union Of Pharmacology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2169386/ https://ncbi.nlm.nih.gov/pubmed/17629959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2007.06.011 |
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