Cox-2 is regulated by toll-like receptor-4 (TLR4) signaling and is important for proliferation and apoptosis in response to intestinal mucosal injury

BACKGROUND: We have recently demonstrated that mice deficient in TLR4 or its adapter molecule MyD88 have increased signs of colitis compared to wild-type (WT) mice following dextran sodium sulfate (DSS)-induced injury. We wished to test the hypothesis that Cox-2 derived PGE(2) is important in TLR4-r...

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Main Authors: Fukata, Masayuki, Chen, Anli, Klepper, Arielle, Krishnareddy, Suneeta, Vamadevan, Arunan S., Thomas, Lisa S., Xu, Ruliang, Inoue, Hiroyasu, Arditi, Moshe, Dannenberg, Andrew J., Abreu, Maria T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169292/
https://ncbi.nlm.nih.gov/pubmed/16952555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2006.06.017
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