Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury

BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the initiation and progression of this disease remain elusive. Previous studies have demonstrated TGFβ1 as a key effector cytokine in t...

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Bibliographic Details
Main Authors: Haider, Yussef, Malizia, Andrea P, Keating, Dominic T, Birch, Mary, Tomlinson, Annette, Martin, Gail, Ferguson, Mark WJ, Doran, Peter P, Egan, Jim J
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169220/
https://ncbi.nlm.nih.gov/pubmed/17883846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-4-18
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