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Drosophila DBT Lacking Protein Kinase Activity Produces Long-Period and Arrhythmic Circadian Behavioral and Molecular Rhythms

A mutation (K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt]). In vitro, DBT protein carrying the K38R mutation (DBT(K/R)) interacted with Period protein (PER) but lacked kinase activity. In cell culture and in flies, DBT(K/R)...

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Bibliografiske detaljer
Main Authors: Muskus, Michael J., Preuss, Fabian, Fan, Jin-Yuan, Bjes, Edward S., Price, Jeffrey L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169192/
https://ncbi.nlm.nih.gov/pubmed/17893330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00680-07
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