Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue

Interaction of the human immunodeficiency virus type 1 (HIV-1) Nef protein with p21-activated kinase 2 (PAK2) has been proposed to play a role in T-cell activation, viral replication, apoptosis, and progression to AIDS. However, these hypotheses were based on results obtained using Nef mutants impai...

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Detalhes bibliográficos
Main Authors: Schindler, Michael, Rajan, Devi, Specht, Anke, Ritter, Carolin, Pulkkinen, Kati, Saksela, Kalle, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169106/
https://ncbi.nlm.nih.gov/pubmed/17881449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01436-07
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