Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) Vpu protein degrades CD4 and counteracts a restriction factor termed tetherin (CD317; Bst-2) to enhance virion release. It has been suggested that both functions can be genetically separated by mutation of a serine residue at position 52. H...

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Main Authors: Schindler, Michael, Rajan, Devi, Banning, Carina, Wimmer, Peter, Koppensteiner, Herwig, Iwanski, Alicja, Specht, Anke, Sauter, Daniel, Dobner, Thomas, Kirchhoff, Frank
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823648/
https://ncbi.nlm.nih.gov/pubmed/20078884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-1
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