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The Tom1L1-Clathrin Heavy Chain Complex Regulates Membrane Partitioning of the Tyrosine Kinase Src Required for Mitogenic and Transforming Activities

Compartmentalization of Src tyrosine kinases (SFK) plays an important role in signal transduction induced by a number of extracellular stimuli. For example, Src mitogenic signaling induced by platelet-derived growth factor (PDGF) is initiated in cholesterol-enriched microdomain caveolae. How this Sr...

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Autors principals: Collin, Guillaume, Franco, Mélanie, Simon, Valérie, Bénistant, Christine, Roche, Serge
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169060/
https://ncbi.nlm.nih.gov/pubmed/17785434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00543-07
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