Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape

CD8(+) cytotoxic T lymphocytes (CTL) are strong mediators of human immunodeficiency virus type 1 (HIV-1) control, yet HIV-1 frequently mutates to escape CTL recognition. In an analysis of sequences in the Los Alamos HIV-1 database, we show that emerging CTL escape mutations were more often present a...

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Bibliographic Details
Main Authors: Liu, Yi, McNevin, John, Zhao, Hong, Tebit, Denis M., Troyer, Ryan M., McSweyn, Matthew, Ghosh, Ananta K., Shriner, Daniel, Arts, Eric J., McElrath, M. Juliana, Mullins, James I.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169017/
https://ncbi.nlm.nih.gov/pubmed/17728222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01277-07
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