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ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits

Human replication factor C (hRFC) is a five-subunit protein complex (p140, p40, p38, p37, and p36) that acts to catalytically load proliferating cell nuclear antigen onto DNA, where it recruits DNA polymerase δ or ɛ to the primer terminus at the expense of ATP, leading to processive DNA synthesis. W...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cai, Jinsong, Yao, Nina, Gibbs, Emma, Finkelstein, Jeff, Phillips, Barbara, O’Donnell, Michael, Hurwitz, Jerard
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21688/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751713/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11607
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