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Characterization of the Mycobacterium tuberculosis 4-Diphosphocytidyl-2-C-Methyl-d-Erythritol Synthase: Potential for Drug Development

Mycobacterium tuberculosis utilizes the methylerythritol phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate and its isomer, dimethylallyl diphosphate, precursors of all isoprenoid compounds. This pathway is of interest as a source of new drug targets, as it is absent from humans and...

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Bibliografske podrobnosti
Main Authors: Eoh, Hyungjin, Brown, Amanda C., Buetow, Lori, Hunter, William N., Parish, Tanya, Kaur, Devinder, Brennan, Patrick J., Crick, Dean C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168624/
https://ncbi.nlm.nih.gov/pubmed/17921290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00925-07
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