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Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

PKN, a fatty acid- and Rho-activated serine/threonine kinase having a catalytic domain highly homologous to protein kinase C (PKC), was cleaved at specific sites in apoptotic Jurkat and U937 cells on Fas ligation and treatment with staurosporin or etoposide, respectively. The cleavage of PKN occurre...

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Autori principali: Takahashi, Mikiko, Mukai, Hideyuki, Toshimori, Masanao, Miyamoto, Masaaki, Ono, Yoshitaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC21681/
https://ncbi.nlm.nih.gov/pubmed/9751706
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