PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation

Abnormal metabotropic glutamate receptor (mGluR) activity could cause brain disorders; however, its regulation has not yet been fully understood. Here, we report that protein kinase N1 (PKN1), a protein kinase expressed predominantly in neurons in the brain, normalizes group 1 mGluR function by upre...

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Publicat a:Commun Biol
Autors principals: Yasuda, Hiroki, Yamamoto, Hikaru, Hanamura, Kenji, Mehruba, Mona, Kawamata, Toshio, Morisaki, Hiromi, Miyamoto, Masaaki, Takada, Shinji, Shirao, Tomoaki, Ono, Yoshitaka, Mukai, Hideyuki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691520/
https://ncbi.nlm.nih.gov/pubmed/33244074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01435-w
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