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Nisin-Controlled Extracellular Production of Interleukin-2 in Lactococcus lactis Strains, without the Requirement for a Signal Peptide Sequence

Secretion of the cytokine interleukin-2 (IL-2) was investigated in Lactococcus lactis using the secretory machinery of the bacteriocin lactococcin A. Surprisingly, the lcnCD transport genes were not essential for mouse IL-2 secretion. Furthermore, expression of a mature mouse IL-2 gene resulted in i...

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Detalhes bibliográficos
Main Authors: Fernández, Antonio, Rodríguez, Juan M., Bongaerts, Roy J., Gasson, Michael J., Horn, Nikki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168050/
https://ncbi.nlm.nih.gov/pubmed/17905884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01247-07
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