Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors

BACKGROUND: The 5,8-disubstituted indolizidines constitute the largest class of poison-frog alkaloids. Some alkaloids have been shown to act as noncompetitive blockers at nicotinic acetylcholine receptors but the proposed structures and the biological activities of most of the 5,8-disubstituted indo...

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Detalhes bibliográficos
Main Authors: Kobayashi, Soushi, Toyooka, Naoki, Zhou, Dejun, Tsuneki, Hiroshi, Wada, Tsutomu, Sasaoka, Toshiyasu, Sakai, Hideki, Nemoto, Hideo, Garraffo, H Martin, Spande, Thomas F, Daly, John W
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2007
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Full Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2164953/
https://ncbi.nlm.nih.gov/pubmed/21931443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1860-5397-3-30
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