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Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus)

A short synthesis of the postulated structure for indolizidine alkaloid 259B with the hydrogens at C5 and C9 entgegen has been achieved with complete control of stereochemistry at C5. Both diastereoisomers at C8 were obtained, but neither proved to be the natural product. The comparison of the mass...

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Detalhes bibliográficos
Main Authors: Nelson, Angela, Garraffo, H Martin, Spande, Thomas F, Daly, John W, Stevenson, Paul J
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2244622/
https://ncbi.nlm.nih.gov/pubmed/18208586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1860-5397-4-6
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