Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27(kip1)

BACKGROUND: Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell (PASMC) in vivo and in vitro, and prostacyclin analogues are thought to inhibit the growth of PASMC. Previous studies suggest that p27(kip1), a kind of cyclin-dependent kinase inhibitor, play an important role in...

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Detalhes bibliográficos
Main Authors: Kadowaki, Maiko, Mizuno, Shiro, Demura, Yoshiki, Ameshima, Shingo, Miyamori, Isamu, Ishizaki, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2164950/
https://ncbi.nlm.nih.gov/pubmed/17974037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-77
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