Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes increase the production of the highly amyloidogenic 42-residue form of amyloid β-protein (Aβ(42)) in a variety of cell lines and transgenic mice. To elucidate the molecular mechanism of this effect, wild-type (wt) or mutant PS1 and PS2...

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Detalles Bibliográficos
Main Authors: Xia, Weiming, Zhang, Jimin, Perez, Ruth, Koo, Edward H., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC21582/
https://ncbi.nlm.nih.gov/pubmed/9223340
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