Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone-mediated autophagy (CMA), a selective lysosomal mechanism for degradation of cytosolic proteins. Pathogenic mutants of α-syn block lyso...

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Main Authors: Martinez-Vicente, Marta, Talloczy, Zsolt, Kaushik, Susmita, Massey, Ashish C., Mazzulli, Joseph, Mosharov, Eugene V., Hodara, Roberto, Fredenburg, Ross, Wu, Du-Chu, Follenzi, Antonia, Dauer, William, Przedborski, Serge, Ischiropoulos, Harry, Lansbury, Peter T., Sulzer, David, Cuervo, Ana Maria
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157565/
https://ncbi.nlm.nih.gov/pubmed/18172548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32806
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