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Toward Full-Sequence De Novo Protein Design with Flexible Templates for Human Beta-Defensin-2
In this article, we introduce and apply our de novo protein design framework, which observes true backbone flexibility, to the redesign of human β-defensin-2, a 41-residue cationic antimicrobial peptide of the innate immune system. The flexible design templates are generated using molecular dynamics...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2157230/ https://ncbi.nlm.nih.gov/pubmed/17827237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.110627 |
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