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Comparative Analysis of P73 and P53 Regulation and Effector Functions

p53 is mutated in ∼50% of human cancers, whereas mutations of the related p73 gene are rare. p73 can activate p53-responsive promoters and induce apoptosis when overexpressed in certain p53-deficient tumor cells. We show that p73 isoforms, p73α and p73β, can each induce permanent growth arrest with...

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Autors principals: Fang, Li, Lee, Sam W., Aaronson, Stuart A.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156169/
https://ncbi.nlm.nih.gov/pubmed/10562283
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