Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α

TRIM5α is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5α-mediated MLV restriction. Our results reveal that changes at tyrosine(336) of human TR...

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Detalhes bibliográficos
Main Authors: Maillard, Pierre V, Reynard, Séverine, Serhan, Fatima, Turelli, Priscilla, Trono, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156100/
https://ncbi.nlm.nih.gov/pubmed/18166079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030200
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