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Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompatibility complex (MHC), and particular alleles from the HLA-DQ and HLA-DR loci contribute...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Patel, Salil D., Cope, Andrew P., Congia, Mauro, Chen, Teddy T., Kim, Eugene, Fugger, Lars, Wherrett, Diane, Sonderstrup-McDevitt, Grete
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223318/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.15.8082
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