Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompatibility complex (MHC), and particular alleles from the HLA-DQ and HLA-DR loci contribute...

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Autors principals: Patel, Salil D., Cope, Andrew P., Congia, Mauro, Chen, Teddy T., Kim, Eugene, Fugger, Lars, Wherrett, Diane, Sonderstrup-McDevitt, Grete
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21560/
https://ncbi.nlm.nih.gov/pubmed/9223318
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