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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally expressed activities involved in V(D)J recombination are also involved in DNA double-strand break repair (DSBR). Two of these are components of the DNA-dependent protein kinase...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gu, Yansong, Jin, Shengfang, Gao, Yijie, Weaver, David T., Alt, Frederick W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences of the USA 1997
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC21559/
https://ncbi.nlm.nih.gov/pubmed/9223317
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