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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth factor-1 (IGF-1) inactivate FoxO transcription factors, a class of highly conserved proteins important in numerous physiological functions. How...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2154463/ https://ncbi.nlm.nih.gov/pubmed/18077353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610290104 |
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