FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth factor-1 (IGF-1) inactivate FoxO transcription factors, a class of highly conserved proteins important in numerous physiological functions. How...

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Bibliografske podrobnosti
Main Authors: Ni, Yan G., Wang, Na, Cao, Dian J., Sachan, Nita, Morris, David J., Gerard, Robert D., Kuro-o, Makoto, Rothermel, Beverly A., Hill, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154463/
https://ncbi.nlm.nih.gov/pubmed/18077353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610290104
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