Mechanical Unloading Activates FoxO3 to Trigger Bnip3‐Dependent Cardiomyocyte Atrophy

BACKGROUND: Mechanical assist device therapy has emerged recently as an important and rapidly expanding therapy in advanced heart failure, triggering in some patients a beneficial reverse remodeling response. However, mechanisms underlying this benefit are unclear. METHODS AND RESULTS: In a model of...

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Detalhes bibliográficos
Main Authors: Cao, Dian J., Jiang, Nan, Blagg, Andrew, Johnstone, Janet L., Gondalia, Raj, Oh, Misook, Luo, Xiang, Yang, Kai‐Chun, Shelton, John M., Rothermel, Beverly A., Gillette, Thomas G., Dorn, Gerald W., Hill, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647287/
https://ncbi.nlm.nih.gov/pubmed/23568341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000016
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