Mechanical Unloading Activates FoxO3 to Trigger Bnip3‐Dependent Cardiomyocyte Atrophy

BACKGROUND: Mechanical assist device therapy has emerged recently as an important and rapidly expanding therapy in advanced heart failure, triggering in some patients a beneficial reverse remodeling response. However, mechanisms underlying this benefit are unclear. METHODS AND RESULTS: In a model of...

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Main Authors: Cao, Dian J., Jiang, Nan, Blagg, Andrew, Johnstone, Janet L., Gondalia, Raj, Oh, Misook, Luo, Xiang, Yang, Kai‐Chun, Shelton, John M., Rothermel, Beverly A., Gillette, Thomas G., Dorn, Gerald W., Hill, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647287/
https://ncbi.nlm.nih.gov/pubmed/23568341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000016
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