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Allosteric intermediates indicate R2 is the liganded hemoglobin end state
Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here, the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, α(2)β(82)CA(82)β and α(2)β(82)ND(82)β, are described at 2.3 Å and 2.6 Å resolution, respectively. Strikingly, these crosslinked hemo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21516/ https://ncbi.nlm.nih.gov/pubmed/9223274 |
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