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Allosteric intermediates indicate R2 is the liganded hemoglobin end state

Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here, the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, α(2)β(82)CA(82)β and α(2)β(82)ND(82)β, are described at 2.3 Å and 2.6 Å resolution, respectively. Strikingly, these crosslinked hemo...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Schumacher, Maria A., Zheleznova, Ekaterina E., Poundstone, Kitty S., Kluger, Ronald, Jones, Richard T., Brennan, Richard G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21516/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223274/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.15.7841
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