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Gating of Acid-sensitive Ion Channel-1: Release of Ca(2+) Block vs. Allosteric Mechanism

The acid-sensitive ion channels (ASICs) are a family of voltage-insensitive sodium channels activated by external protons. A previous study proposed that the mechanism underlying activation of ASIC consists of the removal of a Ca(2+) ion from the channel pore (Immke and McCleskey, 2003). In this wor...

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Autors principals: Zhang, Ping, Sigworth, Fred J., Canessa, Cecilia M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151491/
https://ncbi.nlm.nih.gov/pubmed/16418400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509396
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