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Intracellular Metabolism and Persistence of the Anti-Human Immunodeficiency Virus Activity of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine, a Novel Thymidine Analog

The therapeutic benefits of current antiretroviral therapy are limited by the evolution of drug-resistant virus and long-term toxicity. Novel antiretroviral compounds with activity against drug-resistant viruses are needed. 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a novel thymidine an...

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Detalhes bibliográficos
Main Authors: Paintsil, Elijah, Dutschman, Ginger E., Hu, Rong, Grill, Susan P., Lam, Wing, Baba, Masanori, Tanaka, Hiromichi, Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151449/
https://ncbi.nlm.nih.gov/pubmed/17724147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00692-07
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