Effect of Oral Treatment with Hexadecyloxypropyl-[(S)-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [(S)-HPMPA] or Octadecyloxyethyl-(S)-HPMPA on Cowpox or Vaccinia Virus Infections in Mice

We have previously reported that (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, or (S)-HPMPA, is active in vitro against cowpox virus (CV) and vaccinia virus (VV) but is not active orally in animals. However, the ether lipid esters of (S)-HPMPA, hexadecyloxypropyl-[(S)-HPMPA] [HDP-(S)-HPMPA] an...

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Autori principali: Quenelle, Debra C., Collins, Deborah J., Herrod, Bridgett P., Keith, Kathy A., Trahan, Julissa, Beadle, James R., Hostetler, Karl Y., Kern, Earl R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2007
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151427/
https://ncbi.nlm.nih.gov/pubmed/17846137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00184-07
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