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Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation...
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Main Authors: | , , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
Nature Publishing Group
1998
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151292/ https://ncbi.nlm.nih.gov/pubmed/9472650 |
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