Embryonic Lethality of Molecular Chaperone Hsp47 Knockout Mice Is Associated with Defects in Collagen Biosynthesis

Triple helix formation of procollagen after the assembly of three α-chains at the C-propeptide is a prerequisite for refined structures such as fibers and meshworks. Hsp47 is an ER-resident stress inducible glycoprotein that specifically and transiently binds to newly synthesized procollagens. Howev...

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Autores principales: Nagai, Naoko, Hosokawa, Masanori, Itohara, Shigeyoshi, Adachi, Eijiro, Matsushita, Takatoshi, Hosokawa, Nobuko, Nagata, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150697/
https://ncbi.nlm.nih.gov/pubmed/10995453
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