Activation by Cdc42 and Pip(2) of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

We purified native WASp (Wiskott-Aldrich Syndrome protein) from bovine thymus and studied its ability to stimulate actin nucleation by Arp2/3 complex. WASp alone is inactive in the presence or absence of 0.5 μM GTP-Cdc42. Phosphatidylinositol 4,5 bisphosphate (PIP(2)) micelles allowed WASp to activa...

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Bibliographic Details
Main Authors: Higgs, Henry N., Pollard, Thomas D.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150692/
https://ncbi.nlm.nih.gov/pubmed/10995437
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